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25.12.2021
| SYNTHESIS OF 11-COREY'S 11-DEOXYALDEHYDE - A
PROSTAGLANDIN SYNTHON - FROM 1,5-CYCLOOCTADIENE Dyadchenko, M. A.; Danilova, G. A.; Spanig, I.; Schick, G.; Pivnitskii, K. K. |
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| Source details: | J.Org.Chem.USSR (Engl.Transl.) 1990, 26 : 12 2198-2202. |
| Document type: | Journal |
| CODEN: | JOCYA9 |
| Language: | EN |
| CNR: | 5589330 |
| Original Source: | Zh.Org.Khim. 1990, 26 : 12 2536-2542. |
| CODEN: | ZORKAE |
| Language: | RU |
| Abstract | |
| A new scheme was developed for the synthesis of 6-formyl-cis-2-oxabicyclo[3.3.0]octan-3-ones epimeric with respect to the aldehyde group, which are prostaglandin synthons and 11-deoxy analogs of Corey's aldehyde previously used in prostanoid synthesis.The starting material was 1,5-cyclooctadiene, which gives the synthons with an overall yield of up to 24% in five or eight stages in the two versions of the scheme. | |
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